Co-administration to cells of complex 2 with L-buthionine sulfoximine ( L-BSO), an inhibitor of GSH synthesis, partially restored the anticancer activity towards A2780 ovarian cancer cells. Reactions with GSH hampered the catalytic TH of NAD + to NADH due to the decomposition of the complexes. In addition, the switching on of fluorescence for complex 8 in aqueous solution confirmed release of the chelated DsEnBz ligand in reactions with these thiols. The complexes reacted rapidly with the thiols glutathione (GSH) and N-acetyl- L-cysteine (NAC), forming dinuclear bridged complexes 2− or 2−, with the liberation of the diamine ligand which was detected by LC-MS. All these complexes also showed catalytic activity in transfer hydrogenation (TH) of NAD + to NADH with sodium formate as hydride donor, with TOFs in the range of 2.5–9.7 h −1. Complexes 1–8 have antiproliferative activity against human A2780 ovarian, and A549 lung cancer cells with IC 50 values ranging from 4.1 to >50 μM, although, remarkably, complex 7 was inactive towards A2780 cells, but as potent as the clinical drug cisplatin towards A549 cells. ![]() ![]() The values of their aqua adducts were determined to be high (9.1 to 9.7). The ‘piano-stool’ structure of complex 3,, was confirmed by X-ray crystallography. We have synthesized a series of novel substituted sulfonyl ethylenediamine (en) Ru II arene complexes 1–8 of, where the arene is benzene, HO(CH 2) 2O-phenyl or biphenyl (biph), X = Cl or I, and R 1 is phenyl, 4-Me-phenyl, 4-NO 2-phenyl or dansyl.
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